CAS 4360-12-7 MFCD00135652-(5aR,6S,8R,9S,10R,11R,11As,12Ar,13R)-9-Ethyl-5-Methyl-5A,6,8,9,10,11,11A,12-Octahydro-5H-6,10:11,12A-Dimethanoindolo[3,2-B]Quinolizine-8,13-Diol (5aR,6S,8R,9S,10R,11R,11aS,12aR,13R)-9-乙基-5-甲基-5a,6,8,9,10,11,11a,12-八氢-5H-6,10:11,12a-二甲桥吲哚并[3,2-b]喹啉-8,13-二醇 TAO{mole}

(5aR,6S,8R,9S,10R,11R,11As,12Ar,13R)-9-Ethyl-5-Methyl-5A,6,8,9,10,11,11A,12-Octahydro-5H-6,10:11,12A-Dimethanoindolo[3,2-B]Quinolizine-8,13-Diol (5aR,6S,8R,9S,10R,11R,11aS,12aR,13R)-9-乙基-5-甲基-5a,6,8,9,10,11,11a,12-八氢-5H-6,10:11,12a-二甲桥吲哚并[3,2-b]喹啉-8,13-二醇

CAS 4360-12-7 MFCD00135652

化学结构图

SMILES: CC[C@H]1[C@@H]2C[C@H]3[C@@H]4N(C)c5ccccc5[C@]45C[C@@H]([C@@H]2[C@H]5O)N3[C@@H]1O

化学属性

Mol. Formula	C20H26N2O2
Mol. Weight	326

别名和识别编码

Chemical Name	(5aR,6S,8R,9S,10R,11R,11As,12Ar,13R)-9-Ethyl-5-Methyl-5A,6,8,9,10,11,11A,12-Octahydro-5H-6,10:11,12A-Dimethanoindolo[3,2-B]Quinolizine-8,13-Diol
CAS Number	4360-12-7
Synonym	Ajmalan-17,21-diol, (17R,21-alpha)- (+)-Ajmaline Merabitol Rauwolfine Rhytmaton Ritmos Takycor Tajmalin Rytmalin Tachmalin Ignazin Cardiorythmine Raugalline (17R,21?-Ajmalan-17,21-diol NSC 15627 Gilurytmal Rauwolfin Siddiqui Ajmalin
MDL Number	MFCD00135652
EC Number	224-439-4
Chemical Name Translation	(5aR,6S,8R,9S,10R,11R,11aS,12aR,13R)-9-乙基-5-甲基-5a,6,8,9,10,11,11a,12-八氢-5H-6,10:11,12a-二甲桥吲哚并[3,2-b]喹啉-8,13-二醇
Wiswesser Line Notation	T5 F6 E56 B6 B6/CR/NS A 5BBCEO S EX LN ONT&TTTTJ DQL1 PQ Q2
PubChem Substance ID	6100671
InChI	InChI=1S/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10-,11-,14-,15-,16-,17-,18+,19+,20+/m0/s1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

An antiarrhythmic agent isolated from Rauwolfia serpentina.

安全信息

GHS Symbol

WGK Germany3

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H332 Harmful if inhaled 吸入有害
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

RTECSAX8050000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   31,39,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : 316 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.