CAS 1438-30-8 MFCD00144883-Netropsin 纺锤霉素 TAO{mole}

Netropsin 纺锤霉素

CAS 1438-30-8 MFCD00144883

化学结构图

SMILES: Cn1cc(NC(=O)c2cc(NC(=O)CNC(=N)N)cn2C)cc1C(=O)NCCC(=N)N

化学属性

Mol. Formula	C18H26N10O3
Mol. Weight	430.54
Density	1.52
Stability	对光敏感
Melting Point	168-172°C

别名和识别编码

Chemical Name	N,4'-Bi(pyrrole-2-carboxamide),N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amino)-1,1'- dimethyl-
MDL Number	MFCD00144883
CAS Number	1438-30-8
Beilstein Registry Number	0376913
Synonym	2814-A Antibiotic 1142 Antibiotic T-1384 CH-777-A Congocidin Congocidin Sinanomycin Congocidine F 6 Hydrochloride, Netropsin IA 887 IA-887 K-117 Netropsin Netropsin Hydrochloride Netropsin dihydrochloride hydrate Sinanomycin T 1384 T-1384 纺锤菌素
PubChem Substance ID	4461
Chemical Name Translation	纺锤霉素
Wiswesser Line Notation	T5NJ A1 BVM2VZ EMV- BT5NJ A1 DMYUM&1MYZUM
InChI	InChI=1S/C18H26N10O3/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24)

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

分类

{SNA} Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, N, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 脱氧核糖核酸酶 I, 酶、抑制剂和底物
{SNA} Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiviral,

产品应用

含n-甲基吡咯寡肽，结合到dsDNA的富AT序列上，尤其在小的凹槽位点。这样，它保护该区域免受DNase I和内切核酸酶切割，也抑制拓扑异构酶。
纺锤菌素打乱细胞分裂周期，延长G期，并使分裂停止在G期。
医药上具有抗细菌、真菌、锥体虫、牛痘病毒、噬菌体等作用。

安全信息

WGK Germany3

GHS Symbol

Hazard statements

H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSDW2973000

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P310
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Hazard Codes Xn

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R22 Harmful if swallowed 吞咽有害

Storage condition -20℃保存。避光保存

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1180,1978

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 9,102,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1180,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 2,1180,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 40 mg/L/3H
REFERENCE :
   CRSUBM Cancer Research Supplement.  (Baltimore, MD)  No.1-4, 1953-56.
   Volume(issue)/page/year: 3,69,1955

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 mg/L
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,1144,1980

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MLBRBU Molecular Biology Reports.  (Dr. W. Junk Pub., POB 163, 3300 AD
   Dordrect, Netherlands) V.1-    1973-  Volume(issue)/page/year: 2,135,1975

其他信息

链霉菌Streptomyces netropsis产生的抗生素。溶于水(30mg/ml，80℃，＞0.5mg/ml，25℃)，不溶于一般有机溶剂。盐酸盐吸湿性强。