CAS 53994-73-3 MFCD00151471-Cefaclor 头孢克洛 TAO{mole}

Cefaclor 头孢克洛

CAS 53994-73-3 MFCD00151471

化学结构图

SMILES: N[C@H](C1C=CC=CC=1)C(=O)N[C@H]1[C@H]2SCC(Cl)=C(C(O)=O)N2C1=O

化学属性

Mol. Formula	C15
Mol. Weight	368
TSCA	No

别名和识别编码

Chemical Name	Cefaclor
MDL Number	MFCD00151471
PubChem Substance ID	24278331
Beilstein Registry Number	8176092
EC Number	258-909-5
Synonym	Lilly 99638 Panoral CCL Cefaclor 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid
CAS Number	53994-73-3
Merck Number	14,1912
Wiswesser Line Notation	T46 ANV ES GUTJ CMVYZR& GG HVQ
Chemical Name Translation	头孢克洛

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安全信息

WGK Germany2

GHS Symbol

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏

RTECSXI0363000

Signal word Danger Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S22 Do not breathe dust 不要吸入粉尘；
S24 Avoid contact with skin 避免皮肤接触；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S37 Wear suitable gloves 戴适当手套；

Risk Statements

R42/43

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   27(Suppl 7),765,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   27(Suppl 7),765,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1227 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Skin and Appendages - hair
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   27(Suppl 7),765,19

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 131 mg/kg/7D-I
TOXIC EFFECTS :
   Musculoskeletal - joints
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CMAJAX Canadian Medical Association Journal.  (Canadian Medical Assoc., POB
   8650, Ottawa, ON K1G 0G8, Canada)  V.1-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5500 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   27(Suppl 7),846,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   27(Suppl 7),846,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Effects on Newborn - sex ratio
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   27(Suppl 7),846,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 520 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - muscu