CAS 66104-23-2 MFCD00153859-(6Ar,9R,10Ar)-9-((Methylthio)Methyl)-7-Propyl-4,6,6A,7,8,9,10,10A-Octahydroindolo[4,3-Fg]Quinolinemethanesulfonate (6ar,9r,10ar)-9-((甲硫基)甲基)-7-丙基-4,6,6a,7,8,9,10,10a-八氢吲哚并[4,3-fg]喹啉甲磺酸盐 TAO{mole}

(6Ar,9R,10Ar)-9-((Methylthio)Methyl)-7-Propyl-4,6,6A,7,8,9,10,10A-Octahydroindolo[4,3-Fg]Quinolinemethanesulfonate (6ar,9r,10ar)-9-((甲硫基)甲基)-7-丙基-4,6,6a,7,8,9,10,10a-八氢吲哚并[4,3-fg]喹啉甲磺酸盐

CAS 66104-23-2 MFCD00153859

化学结构图

SMILES: CCCN1C[C@@H](C[C@H]2[C@H]1CC1=CNC3C=CC=C2C1=3)CSC.CS(O)(=O)=O

化学属性

Mol. Formula	C20H30N2O3S2
Mol. Weight	411

别名和识别编码

Chemical Name	(6Ar,9R,10Ar)-9-((Methylthio)Methyl)-7-Propyl-4,6,6A,7,8,9,10,10A-Octahydroindolo[4,3-Fg]Quinolinemethanesulfonate
CAS Number	66104-23-2
Synonym	MPE 8-beta-((Methylthio)methyl)-6-propylergoline monomethane sulfonate 8-beta-((Methylthio)methyl)-6-propylergoline methanesulfonate Celance Pergolide mesylate (8?)-8-[(Methylthio)methyl]-6-propylergoline Mesylate LY127809 Pergolide mesylate salt Permax Nopar
PubChem Substance ID	24277927
MDL Number	MFCD00153859
Chemical Name Translation	(6ar,9r,10ar)-9-((甲硫基)甲基)-7-丙基-4,6,6a,7,8,9,10,10a-八氢吲哚并[4,3-fg]喹啉甲磺酸盐

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

分类

Neurochemicals
Pharmaceuticals
Intermediates & Fine Chemicals,
{SNA} Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, Dopaminergics - Agonists, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, P, Proteins and Derivatives, Valeant

产品应用

A dopaminergic agonist that also decrease plasma prolactin concentrations. An antiparkinsonian agent.

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H300 Fatal if swallowed 吞食致命

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSKE6345000

Precautionary statements

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Hazard Codes T+

Risk Statements

R28 Very toxic if swallowed 吞咽极毒

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >20 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,278,1994

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >25 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,278,1994

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,278,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 54 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 666 mg/kg
SEX/DURATION            : male 9 week(s) pre-mating
                          female 2 week(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,1177,1994

TYPE OF TEST            :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 6500 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 48 mg/kg
SEX/DURATION            : female 15-20 day(s) after conception
                          lactating female 10 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - postpartum
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   13,297,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 666 mg/kg
SEX/DURATION            : male 9 week(s) pre-mating

UN Number

Packing GroupIII