CAS 9073-60-3 MFCD00163244-beta-Lactamase β-内酰胺酶 TAO{mole}

beta-Lactamase β-内酰胺酶

CAS 9073-60-3 MFCD00163244

化学结构图

SMILES: O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)O)=C(CSc3ccc([N+](=O)[O-])c(C(=O)O)c3)CSC12

化学属性

Solubility	Unit Definition One unit will hydrolyze 1.0 μmole of indicated substrate per min at pH 7.0 at 25 °C. Sold as benzylpenicillin units. This International Unit (using benzylpenicillin as substrate) is approximately equal to 600 Levy or 75 Pollock units.

别名和识别编码

CAS Number	9073-60-3
Synonym	Cefinase Cephalosporinase Penicillin amido-β-lactam hydrolase Penicillinase; Penicilloyl serine transferase; Carbapenem hydrolase; Carbapenemase; Cefinase; Cefotaximase; Ceftazidimase; Ceftazimidase; Cefuroximase; Cephalosporinase; Cephamycinase beta-Lactamase β-Lactamase I β-Lactamase II Cephalosporinase Penicillin amido-β-lactam hydrolase Penicillinase from Enterobacter cloacae β-Lactamase I from Bacillus cereus β-Lactamase I from Bacillus cereus β-Lactamase II Cephalosporinase Penicillin amido-β-lactam hydrolase β-Lactamase II β-内酰胺酶 β-内酰胺酶;青霉素酶
Chemical Name	β-lactamase
Chemical Name Translation	β-内酰胺酶
MDL Number	MFCD00131819
PubChem Substance ID	133358
InChI	InChI=1S/C21H17N3O8S3/c25-15(7-11-2-1-5-33-11)22-16-18(26)23-17(21(29)30)10(9-35-19(16)23)8-34-12-3-4-14(24(31)32)13(6-12)20(27)28/h1-6,16,19H,7-9H2,(H,22,25)(H,27,28)(H,29,30)/t16-,19-/m1/s1

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产品应用

应用于环境中残留青霉素的清除；医疗器械残留青霉素的清以及青霉素效价测定中本底的清除；
用基因重组技术在大肠杆菌表达体系生产β-内酰胺酶（序列来自大肠杆菌），属于分子生物学分类A类，BUSH分类第二类的青霉素酶，学名为TEM1，目前有天然酶和融合酶两种形式提供。

安全信息

Storage condition 保存条件： 2-8℃ 储存温度2-8℃,充氩保存

RTECSOD2265000

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #79-59295

Hazard Codes Xn

GHS Symbol

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

WGK Germany3

Signal word Danger

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S22 Do not breathe dust 不要吸入粉尘；

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

Risk Statements

R42/43

其他信息

可水解β-内酰胺类抗生素。已发现二百多种β-内酰胺酶。青霉素酶的分类方法主要有两种，分子生物学方法和BUSH法。分子生物学法将酶分为四类。A类酶包括多种质粒编码的青霉素酶，活性部位为丝氨酸残基，分子量为29kDa。B类酶为金属酶，由染色体或质粒编码，酶活性需锌离子参与，可被乙二胺四乙酸（EDTA）抑制。C类酶的活性部位为丝氨酸残基，分子量为39kDa，其产生与诱导剂有关。C类酶主要指染色体编码的头孢菌素酶（AmpC酶）。D类酶又称为OXA型（水解苯唑西林）β-内酰胺酶。另一种分类方法为BUSH