CAS 9005-65-6 MFCD00082107-Tween 80 吐温80 TAO{mole}

Tween 80 吐温80

CAS 9005-65-6 MFCD00082107

化学结构图

SMILES: CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO

化学属性

Density	1.064
Mol. Formula	C32H60O10
Refractive index	n20/D 1.472(lit.)
Flash Point	295°C(lit.)
TSCA	Yes
Boiling Point	>100°
Mol. Weight	604.81
Vapor Pressure	<;1 mmHg ( 20 °C)
Solubility	5-10 G/100 ML AT 23 ºC
Stability	对光敏感
Appearance	viscous liquid

别名和识别编码

Synonym	Capmul poe-O Crill S 10 Glycos Glycosperse O-20X Hodag SVO 9 MONTANOX(R) 80 DF VG Nikkol TO PEG-3 失水山梨醇油酸酯 PEG-6 失水山梨醇油酸 POE（20）失水山梨醇单油酸酯 POLYETHYLENE GLYCOL SORBITAN MONOOLEATE POLYOXYETHYLENE ORBITANE MONOOLEATE Polye Polyoxyethylene sorbitan Polysorba Polysorbate 80 Polysorbate 80; Polyoxyethylene Sorbitan Monooleate Protasorb O-20 Sorbon T 80 T-80乳化剂 TWEEN Tween 81 吐温® 80 吐温-80 吐温-81 聚山梨醇酯 80 聚氧乙烯山梨糖醇酐单油酸酯聚环氧乙烷脱水山梨糖醇单油酸酯溶液聚山梨醇酯-81 聚氧乙烯山梨糖醇酐单油酸酯脱水山梨醇单油酸酯聚氧乙烯醚
MDL Number	MFCD00082107
CAS Number	9005-65-6
Merck Number	7582
PubChem Substance ID	5281955
Chemical Name	Tween 80
EC Number	500-019-9
Chemical Name Translation	吐温80
LabNetwork Molecule ID	LN02020128
InChI	InChI=1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-26-28(38-21-18-33)32-31(41-23-20-35)29(27-42-32)39-22-19-34/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

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品牌质保精细包装现货库存一流品牌服务

产品应用

为非离子型去垢剂。用于从哺乳动物细胞系中选择性蛋白提取和分离细胞核。

安全信息

WGK Germany1

RTECSWG2932500

Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves

GHS Symbol

Hazard statements

H319 Causes serious eye irritation 严重刺激眼睛
H320 Causes eye irritation 刺激眼睛

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。

Signal word Warning

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Storage condition Store at RT. 密封避光保存。

Hazard Codes Xi

Risk Statements

R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2163 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - adrenal cortex tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-415,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg/27W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 9,463,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6804 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 35,804,1985

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Cardiac - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,1586,1978

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Cardiac - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 28,1586,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 25 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 26,459,1991

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TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 20 ppm
REFERENCE :
   ENPBBC Environmental Physiology and Biochemistry.  (Copenhagen, Denmark)
   V.2-5, 1972-75. Discontinued.  Volume(issue)/page/year: 5,84,1975

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 ppm
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 45,630,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 635 gm/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 60,489,1956

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 uL/kg
SEX/DURATION            : lactating female 4 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Effects on Newborn - physical
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   31,183,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1270 gm/kg
SEX/DURATION            : female 84 day(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 60,489,1956

其他信息

所属类别三:化工助剂: 工业表面活性剂: 非离子表面活性剂
使用限量:GB 2760-96(g/kg)：雪糕、冰淇淋，1.0；牛乳1.5；乳化天然色素10。 FDA，§172.840(2000，mg/kg)：冰淇淋、冷冻甜食，0.1%；酵母消泡4；腌渍制品分散剂500；食盐表面处理剂10；起酥油1%；顶端料0.4%；发泡剂0.0175%；明胶甜食分散剂0.082%；干酪生产中消泡剂0.008%。FAO/WHO(1984)：酸黄瓜500mg/kg；冷饮10g/kg(以最终产品计，单用或与其他乳化剂、稳定剂和增稠剂合用量)。
所属类别一:食品添加剂: 乳化剂、增稠剂和稳定剂
Form @ 25
在乳制品中的应用:蛋白饮料中常使用的有吐温60(HLB值14.9)和吐温80 (HLB值15.0)。由于其HLB值较高，价格又远低于等HLB值的蔗糖酯等乳化剂，通常与低HLB值的单甘酯、司盘、蔗糖酯等合用，以适应各类蛋白饮料的需要。在植物蛋白乳饮料中常用的乳化剂以蔗糖酯和单甘酯、司盘、吐温、卵磷脂为主。通常以两种以上的乳化剂配合使用，这样效果比单一使用时更好。乳化剂的添加量一般为油脂量的12%左右。以上信息由Chemicalbook晓楠编辑整理。
参考质量标准一:FAO/WHO(1981) 温州清明化工厂标准氧乙烯含量(以C2H4O计)/% 65.0～69.5 - 酸值 ≤2 2.2 水分/% ≤3 3 硫酸盐灰分/% ≤0.25 - 灰分/% - ≤0.15 砷(以As计)/% ≤0.0003 0.0001 重金属(以Pb计)/% ≤0.001 0.001 皂化值 45～55 45～60 羟值 65～80 65～80 碘值 - 18~24
生产方法:在甲醇钠(或乙醇钠)的催化下、130～170℃时，Span-80中通人一定量的环氧乙烷发生加成反应得产品。
毒害物质数据:9005-65-6(Hazardous Substances Data)
吐温 80价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30189828 吐温80;吐混80;聚乙氧基油酸山梨糖醇;聚环氧乙烷脱水山梨糖醇单油酸酯;聚氧乙烯山梨糖醇酐单油酸酯 500g 22元 2011/08/23 HW6611301 吐温 80 1L 1060元 2011/08/23 xp400176 吐温80;吐混80;聚乙氧基油酸山梨糖醇;聚环氧乙烷脱水山梨糖醇单油酸酯;聚氧乙烯山梨糖醇酐单油酸酯 100ml 27.69元
毒性:ADI 0～25mg/kg(FAO/WFO，2001)。可安全用于食品(FDA，§172.840，2000)。 LD50 25g/kg(小鼠，经口)。
化学基团
非离子乳化剂:吐温 80是由人工合成的一种非离子乳化剂，广泛用于化妆品、食品领域和药物制剂中。其工业制造方法是：在碱催化下环氧乙烷与山梨醇脂肪酸偏酯和山梨醇酐脂肪酸偏酯进行加成反应，其中每1mol山梨醇或相应的山梨醇酐加成20mol环氧乙烷。这一类乳化剂是由美国ICI公司首先开发的，吐温是ICI公司给这一类乳化剂所起的商品名，并根据合成过程中使用的不同脂肪酸类型给予不同的编号构成完整的商品名，如吐温60、吐温80 等。由于应用广泛和方便记忆，吐温已成为聚山梨醇酸酯在行业内的通用商品名。性状：商品化的聚山梨醇酸酯有聚山梨醇酸酯20、聚山梨醇酸酯 40、聚山梨醇酸酯60、聚山梨醇酸酯 65、聚山梨醇酸酯80五种，通常也称为吐温20、吐温40、吐温60、吐温65、吐温80。吐温在常温下呈浅米色至浅黄色膏体状
吐温 80价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30189828 吐温80;吐混80;聚乙氧基油酸山梨糖醇;聚环氧乙烷脱水山梨糖醇单油酸酯;聚氧乙烯山梨糖醇酐单油酸酯 500g 22元 2011/08/23 HW6611301 吐温 80 1L 1
配伍禁忌:吐温同多种物质，特别是苯酚、鞣酸、焦油及焦油类物质会发生变色或沉淀反应。吐温还影响防腐剂羟苯酯类的抗菌活性。吐温80能与尼泊金甲、丙、丁酯发生键合，键合能力随温度上升而下降。吐温80还能降低三氯叔丁醇、苯甲醇等多种防腐剂的防腐能力，但对甲醛、山梨酸、苯甲酸以及醋酸苯