H-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH
CAS 106612-94-6 MFCD00167940
化学结构图
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2C=CC=CC1=2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O
化学属性
| Mol. Formula | C151H228N40O47 |
|---|---|
| Mol. Weight | 3355.67 |
别名和识别编码
| Chemical Name | Glucagon-Like Peptide 1 Fragment 7-37 human |
|---|---|
| Synonym | GLP-1, 7-37 GLP-1, 7-37 Preproglucagon 78-108 Preproglucagon 78-108 |
| MDL Number | MFCD00167940 |
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资金保障
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分类
- {SNA} Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, GLP-1 Receptor Ligands, Gastrointestinal Peptides, Glucagon, Glucagon and Glucagon-Like Peptides, Glucagon-Like Peptides, Hormones, Obesity Peptides, Other Protein/Peptide Hormones, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学, 肥胖研究
- Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, GLP-1 Receptor Ligands, Gastrointestinal Peptides, Glucagon, Glucagon and Glucagon-Like Peptides, Glucagon-Like Pepti
相关文献及参考
- [2]. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7.
- Orskov, C., et al., Complete sequences of glucagon-like peptide-1 from human and pig small intestine. J. Biol. Chem. 264 , 12826, (1989) 摘要
- Rouille, Y., et al., Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. J. Biol. Chem. 270 , 26488, (1995) 摘要
- [1]. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chem
- [1]. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004).
