CAS 797-63-7 MFCD00199013-Norgestrel 左炔诺孕酮 TAO{mole}

Norgestrel 左炔诺孕酮

CAS 797-63-7 MFCD00199013

化学结构图

SMILES: C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21CC

化学属性

Mol. Formula	C27H36O8
Mol. Weight	489
Melting Point	234-238

别名和识别编码

Chemical Name	Levonorgestrel, 98%
MDL Number	MFCD00199013
CAS Number	797-63-7
PubChem Substance ID	13109
EC Number	212-349-8
Synonym	(-)-Levonorgestrel, Norgestimate USP Related Compound A 13-Ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one 17-Ethynyl-18-methyl-19-nortestosterone 17-alpha-Ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one 17-beta-Hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)- 18,19-双失碳孕甾-4-烯-20-炔基-3-酮 18,19-双失碳-13β-乙基-17β-羟基-孕甾-4-烯-20-炔基-3-酮左旋甲基炔诺酮左炔诺孕酮甲基炔诺酮 18-Methyl-17-alpha-ethynyl-19-nortestosterone Capronor Cerazet D Norgestrel D(-)-13beta-Ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one D(-)-炔诺孕酮 D-Norgestrel Levonorgestrel Microlut Microval Mirena Nor NorLevo Norgeston Norplant
Reaxys-RN	6067808
Merck Number	6704
Chemical Name Translation	左炔诺孕酮
Wiswesser Line Notation	L E5 B666 OV MUTJ E2 FQ F1UU1 -D
Beilstein Registry Number	6067808
LabNetwork Molecule ID	LN01304553
InChI	InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1

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安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P317
P302+P352
P304+P312
P304+P340
P305+P351+P338
P308+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P317
P318
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P317
P337+P317
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害
H351 Suspected of causing cancer 怀疑致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

RTECSJF8225000

Signal word Danger Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes T Xn

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R60 May impair fertility 可能降低生殖能力

Storage condition 0-10 0-10°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29 mg/kg/69W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 168,1190,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 1600 ug/kg
SEX/DURATION            : female 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 12,529,1975

TYPE OF TEST            : TD

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 300 ug/kg
SEX/DURATION            : female 2 day(s) pre-mating
                          female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 117,167,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 109 ug/kg
SEX/DURATION            : female 26 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sp

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 1800 ug/kg
SEX/DURATION            : female 43 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :