CAS 77191-36-7 MFCD00209882-N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide N-(2,6-二甲苯基)-2-氯乙酰胺 TAO{mole}

N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide N-(2,6-二甲苯基)-2-氯乙酰胺

CAS 77191-36-7 MFCD00209882

化学结构图

SMILES: CC1C=CC=C(C)C=1NC(=O)CN1CCCC1=O

化学属性

Mol. Formula	C14H18N2O2
Mol. Weight	246.31
Melting Point	149.0 to 153.0 deg-C

别名和识别编码

Chemical Name	N-(2,6-Dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
Synonym	(2-(2-oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide) DM-9384 DM 9384 DMPPA N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide Nefiracetam
MDL Number	MFCD00209882
Beilstein Registry Number	6848330
CAS Number	77191-36-7
PubChem Substance ID	253660872
Chemical Name Translation	N-(2,6-二甲苯基)-2-氯乙酰胺
Reaxys-RN	6848330
Merck Number	6439

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安全信息

RTECSUX9655650

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P301+P312+P330
P308+P313
P330 Rinse mouth. 漱口
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

WGK Germany3

Signal word

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1940 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,211,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1182 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,211,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,211,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11 gm/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,239,1994

UN Number

Packing GroupIII