CAS 553-21-9 MFCD00210262-(3aS,6E,10E,11aR)-6,10-Dimethyl-3-Methylene-3A,4,5,8,9,11A-Hexahydrocyclodeca[B]Furan-2(3H)-One (3aS,6E,10E,11aR)-6,10-二甲基-3-亚甲基-3,3a,4,5,8,9-六氢环癸烷并[b]呋喃-2(11aH)-酮 TAO{mole}

(3aS,6E,10E,11aR)-6,10-Dimethyl-3-Methylene-3A,4,5,8,9,11A-Hexahydrocyclodeca[B]Furan-2(3H)-One (3aS,6E,10E,11aR)-6,10-二甲基-3-亚甲基-3,3a,4,5,8,9-六氢环癸烷并[b]呋喃-2(11aH)-酮

CAS 553-21-9 MFCD00210262

化学结构图

SMILES: CC1CCC=C(C)CC[C@@H]2[C@@H](C=1)OC(=O)C2=C |c:4,11,&1:9,10|

化学属性

Mol. Formula	C15H20O2
Mol. Weight	232
Density	1.03
Solubility	Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).,

别名和识别编码

Chemical Name	(3aS,6E,10E,11aR)-6,10-Dimethyl-3-Methylene-3A,4,5,8,9,11A-Hexahydrocyclodeca[B]Furan-2(3H)-One
Synonym	(e,e)-6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oicacidgamma-lactone Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a- 木香烃内酯 (3aS,6E,10E)-3aβ,4,5,8,9,11aβ-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one CUSTUNOLIDE Costunolide Costus lactone (3AS,6E,10E,11AR)-3A,4,5,8,9,11A-HEXAHYDRO-6,10-DIMETHYL-3-METHYLENE-CYCLODECA[B]FURAN-2(3H)-ONE (3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one Costunolid (3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3aβ,4,5,8,9,11aα-octahydrocyclodeca[b]furan-2-one hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)- costunolid
CAS Number	553-21-9
MDL Number	MFCD00210262
Chemical Name Translation	(3aS,6E,10E,11aR)-6,10-二甲基-3-亚甲基-3,3a,4,5,8,9-六氢环癸烷并[b]呋喃-2(11aH)-酮
PubChem Substance ID	354335714
Reaxys-RN	14451

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产品应用

A sequiterpene lactone that inhibits telomerase

安全信息

RTECSLY4270000

GHS Symbol

Safety Statements

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352+P332+P313+P362+P364
P305+P351+P338+P337+P313

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

WGK Germany3

Signal word Warning

Hazard Codes Xi

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Storage condition -20°C 储存温度-20°C

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 12500 ppb
REFERENCE :
   BSECBU Biochemical Systematics and Ecology.  (Pergamon Press Inc., Maxwell
   House, Fairview Park, Elmsford, NY 10523)  V.2-     1974-
   Volume(issue)/page/year: 13,365,1985

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 6150 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   30,3005,1981

其他信息

MOL 文件:553-21-9.mol
外观性质:淡黄色粉末。
Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway
Sigma Aldrich:553-21-9(sigmaaldrich)