2,2,5,7,8-Pentamethyl-6-chromanol 2,2,5,7,8-五甲基-6-苯并甲醇
CAS 950-99-2 MFCD00210347
化学结构图
SMILES: Cc1c(C)c2c(c(C)c1O)CCC(C)(C)O2
化学属性
| Mol. Formula | C14H20O2 |
|---|---|
| Mol. Weight | 220.31 |
| Melting Point | 89-91 °C(lit.) |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 2,2,5,7,8-Pentamethyl-6-Chromanol |
|---|---|
| MDL Number | MFCD00210347 |
| CAS Number | 950-99-2 |
| PubChem Substance ID | 99479 |
| Synonym | 10,10,2,6,5-pentamethyl-1-hydroxychroman 2,2,5,7,8-pentamethyl-1-hydroxychroman 2,2,5,7,8-pentamethyl-6-chromanol 3,4-二氢-2,2,5,7,8-五甲基-2H-1-苯并吡喃-6-酚 APC100; APC 100; APC-100; Chromane C1; Chroman C1; PMHCR; PMCol; NSC 226236; NSC226236; UNII7G73627R36; NSC226236; AC11926; BP11301; LS39406; DB031296; Z3168. Pubchem CID 99479; 22578Pentamethyl6chromanol. PMHCR chroman C1 chromane C1 chromanol |
| Chemical Name Translation | 2,2,5,7,8-五甲基-6-苯并甲醇 |
| Formula | C14H20O2 |
| IUPAC Name | 2,2,5,7,8-pentamethylchroman-6-ol. |
| InChIKey | SEBPXHSZHLFWRL-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H20O2/c1-8-9(2)13-11(10(3)12(8)15)6-7-14(4,5)16-13/h15H,6-7H2,1-5H3 |
| Canonical SMILES | OC1=C(C)C(CCC(C)(C)O2)=C2C(C)=C1C |
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分类
- {SNA} Benzopyrans, Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks
产品应用
- APC-100 is an orally available, vitamin E derivative and androgen receptor (AR) antagonist with potential anti-oxidant, chemopreventative and antineoplastic activity. APC-100 binds to ARs in target tissues thereby inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. By inhibiting the formation of the complex between androgen activated AR- and the AP1 transcription factor JunD, the expression of androgen-responsive genes is blocked. One such gene is spermidine/spermine N1-acetyl transferase gene (SSAT) which is responsible for the breakdown of polyamines, which are produced in high levels by prostatic epithelial cells, into reactive oxygen species (ROS) that cause cellular damage. APC-100 may ultimately lead to an inhibition of growth in both AR-dependent and AR-independent prostate tumor cells.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P319
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P332+P313
- P332+P317
- P337+P313
- P337+P317
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P362+P364
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
