CAS 21256-18-8 MFCD00215977-Oxaprozin 奥沙普嗪 TAO{mole}

Oxaprozin 奥沙普嗪

CAS 21256-18-8 MFCD00215977

化学结构图

SMILES: OC(=O)CCC1=NC(=C(O1)C1C=CC=CC=1)C1C=CC=CC=1

化学属性

Mol. Formula	C18H15NO3
Mol. Weight	293
Melting Point	161-165

别名和识别编码

Chemical Name	Oxaprozin
CAS Number	21256-18-8
Synonym	Wy 21743 4,5-Diphenyl-2-oxazolepropanoic Acid 4,5-Diphenyl-2-oxazolepropionic acid WY-21743 2-Oxazolepropanoic acid, 4,5-diphenyl- NSC 310839 Oxapro Daypro 4,5-Diphenyl-2-oxazolepropanoic acid; 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid Duraprost Alvo Durapro 4,5-Diphenyl-2-oxazolepropanoic acid 3-(4,5-Diphenyloxazol-2-yl)propionic Acid 4,5-Diphenyl-2-oxazolepropanoic acid ?-(4,5-D 4,5-Diphenyl-2-oxazolepropionic Acid
MDL Number	MFCD00215977
PubChem Substance ID	160871033
EC Number	244-296-1
Alfabeta Name	DIPHENYLOXAZOLYLPROPANOICACID 345132()------,,
Chemical Name Translation	奥沙普嗪
Reaxys-RN	1083168
Merck Number	6924
Beilstein Registry Number	1083168

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分类

{SNA} A to C, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cyclooxygenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Immune Cell Signaling and Blood, Immune System Regulation,
{
Heterocycles
Pharmaceuticals
Intermediates & Fine Chemicals
{SNA} A to C, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclooxygenase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, O, Pfizer Compounds
Aromatics

产品应用

Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).

安全信息

WGK Germany3

RTECSRP6990000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Hazard Codes Xn

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

Warnings IRRITANT

Signal word

Precautionary statements

P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。

Hazard statements

H303 May be harmfully swallowed 吞食可能有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 124 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - other changes
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 15,359,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dos

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 376 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - other changes
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 15,359,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - other changes
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 15,359,1984

{hazar

TYPE OF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 18,528,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 520 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 15,250,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 220 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 15,225,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       :

GHS Symbol