CAS 22994-85-0 MFCD00243089-N-Benzyl-2-Nitro-1H-Imidazole-1-Acetamide 苄哒唑 TAO{mole}

N-Benzyl-2-Nitro-1H-Imidazole-1-Acetamide 苄哒唑

CAS 22994-85-0 MFCD00243089

化学结构图

SMILES: [O-][N+](=O)C1=NC=CN1CC(=O)NCC1C=CC=CC=1

化学属性

Mol. Formula	C12H12N4O3
Mol. Weight	260.25
Melting Point	189-192 °C(lit.)

别名和识别编码

Chemical Name	N-Benzyl-2-Nitro-1H-Imidazole-1-Acetamide
CAS Number	22994-85-0
Synonym	Benzonidazole N-Benzyl-2-nitroimidazole-1-acetamide Benzonidazol Benznidazole 苄哒唑 N-Benzyl-2-nitro-1-imidazoleacetamide N-Benzyl-2-nitro-1H-imidazole-1-acetamide Radanil Acetamide, N-benzyl-2-(nitroimidazol-1-yl)- Ro 71051 Ro 0 N-Benzyl-2-nitro-Imidazole-1-acetamide 2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide N-Benzyl-2-nitroimidazol-1-yl-acetamide NSC 299972 1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-
MDL Number	MFCD00243089
PubChem Substance ID	24866267
Chemical Name Translation	苄哒唑
Wiswesser Line Notation	T5N CNJ A1VM1R& BNW
Beilstein Registry Number	0551486

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产品应用

Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present sever

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

RTECSNI3340000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xi

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Human
DOSE/DURATION           : 150 mg/kg/30D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,217,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   IDZAAW Japanese Journal of Genetics.  Idengaku Zasshi.  (Genetics Soc. of
   Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan)  V.1-    1921-
   Volume(issue)/page/year: 58,505,1983

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 380 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   34,1457,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   BJMRDK Brazilian Journal of Medical and Biological Research.  (Associacao
   Brasileira de Divulg

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 31,149,1975

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 25 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 230,305,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 8 gm/kg
SEX/DURATION            : male 8 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   COBIEJ Communicaciones Biologicas.  (Communicaciones Biologicas, c/o Dr.
   Amanda Pellegrino de Iraldi, Instituto de Biologia Cellular, Faculated de
   Medicina, Paraguay 2155, Buenos Aires, 1121, Argentina)  V.1-    1982-
   Volume(issue)/page/year: 8,251,1990