1Ah-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-Carboxamide 1AH-二苯并[b,f]环氧乙烯并[2,3-d]氮杂卓-6(10bH)-甲酰胺
CAS 36507-30-9 MFCD00467137
化学结构图
SMILES: NC(=O)N1C2C=CC=CC=2C2OC2C2C=CC=CC1=2
化学属性
| Mol. Formula | C15H12N2O2 |
|---|---|
| Mol. Weight | 252.29 |
别名和识别编码
| Chemical Name | 1Ah-Dibenzo[B,F]Oxireno[2,3-D]Azepine-6(10Bh)-Carboxamide |
|---|---|
| CAS Number | 36507-30-9 |
| Synonym | GP 49-023 10,11-Epoxycarbamazepine 1a,10b-Dihydro-6H-dibenzo(b,f)oxireno[d]azepine-6-carboxamide Carbamazepine 10,11-oxide 10,11-Dihydro-10,11-epoxycarbamazepine 1a,10b-Dihydro-6H-dibenz(b,f)oxiren(d)azepine-6-carboxamide 1a,10b-Dihdyro-6H-dibenzo[b,f]oxireno[d]azepine-6-carboxamide Carbamazepine 10,11-epoxide |
| MDL Number | MFCD00467137 |
| PubChem Substance ID | 24892674 |
| Chemical Name Translation | 1AH-二苯并[b,f]环氧乙烯并[2,3-d]氮杂卓-6(10bH)-甲酰胺 |
| Beilstein Registry Number | 1219988 |
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分类
- Alphabetic, Analytical Standards, Analytical/Chromatography, C, CA - CG, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Others, Solutions
- {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, C, CA - CG, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Others, Solutions
产品应用
- A metabolite of Carbamazepine (C175840).
相关文献及参考
- Bellucci, G., et al.: J. Med. Chem., 30, 768 (1987),
- Johannessen, S., et al.: Ther. Drug. Monit., 27, 710 (2005),
- Bialer, M., et al.: Expert Opin. Invest. Drugs, 15, 637 (2006),
- Bellucci, G., et al. J. Med. Chem. 30 , 768, (1987) 摘要
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 420 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 37,12,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 9600 mg/kg
SEX/DURATION : female 2 week(s) pre-mating
female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 279,1237,1996TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 32 gm/kg
SEX/DURATION : female 2 week(s) pre-mating
female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 279,1237,1996TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 19200 mg/kg
SEX/DURATION : female 2 week(s) pre-mating
female 1-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 279,1237,1996