UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
CAS 313367-92-9 MFCD00489199
化学结构图
SMILES: COc1ccc(-c2cnc(-c3cccc4c3-c3ccccc3C4=O)o2)cc1
化学属性
| Mol. Formula | C23H15NO3 |
|---|---|
| Mol. Weight | 353.37 |
| Appearance | Light yellow to yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly. |
|---|---|
| Synonym | 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one UA62784 UA62784, UA62784, UA 62784 |
| MDL Number | MFCD00489199 |
| PubChem Substance ID | 329827627 |
| Chemical Name Translation | |
| Formula | C23H15NO3 |
| IUPAC Name | 4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one |
| InChIKey | SVICLWPFAQYZLX-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3 |
| Canonical SMILES | O=C1C2=C(C3=C1C=CC=C3)C(C4=NC=C(C5=CC=C(OC)C=C5)O4)=CC=C2 |
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分类
- {SNA} Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience
- {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, U, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
