CAS 65567-32-0 MFCD00754497-(R)-5-Ethyl-5-phenylimidazolidine-2,4-dione (R)-5-乙基-5-苯基咪唑烷-2,4-二酮 TAO{mole}

(R)-5-Ethyl-5-phenylimidazolidine-2,4-dione (R)-5-乙基-5-苯基咪唑烷-2,4-二酮

CAS 65567-32-0 MFCD00754497

化学结构图

SMILES: CC[C@@]1(NC(=O)NC1=O)C1C=CC=CC=1

化学属性

Mol. Formula	C11H12N2O2
Mol. Weight	204.23

别名和识别编码

Chemical Name	(R)-5-Ethyl-5-phenylimidazolidine-2,4-dione
Synonym	(-)-5-Ethyl-5-phenylhydantoin (-)-Nirvanol (R)-(-)-5-Ethyl-5-phenyl-2,4-imidazolidinedione (R)-(-)-5-Ethyl-5-phenylhydantoin (R)-(-)-Nirvanol (R)-5-Ethyl-5-phenyl-2,4-imidazolidinedione (R)-Nirvanol 2,4-Imidazolidinedione, 5-ethyl-5-phenyl-, (R)- l-5-Ethyl-5-phenylhydantoin l-Nirvanol
MDL Number	MFCD00754497
CAS Number	65567-32-0
Beilstein Registry Number	0085312
PubChem Substance ID	329827655
Chemical Name Translation	(R)-5-乙基-5-苯基咪唑烷-2,4-二酮

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安全信息

RTECSMU2452000

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

WGK Germany2

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Hazard Codes Xn

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 47,209,1933

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 47,209,1933

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 47,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BBIADT Biomedica Biochimica Acta.  (Akademie-Verlag GmbH, Postfach 1233,
   Berlin DDR-1086, Ger. Dem. Rep.)  V.42-     1983-  Volume(issue)/page/year:
   46,623,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 97 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 221,228,1982