CAS 42017-89-0 MFCD00792461-Fenofibric acid 非诺贝特酸 TAO{mole}

Fenofibric acid 非诺贝特酸

CAS 42017-89-0 MFCD00792461

化学结构图

SMILES: CC(C)(OC1C=CC(=CC=1)C(=O)C1C=CC(Cl)=CC=1)C(O)=O

化学属性

Mol. Formula	C17H15ClO4
Mol. Weight	319
Melting Point	179.0 to 183.0 deg-C

别名和识别编码

Chemical Name	Fenofibric acid
CAS Number	42017-89-0
Synonym	A-1081 FENOFIBRIC ACID 2-[4-(4-CHLORO-BENZOYL)-PHENOXY]-2-METHYL-PROPIONIC ACID (FENOFIBRIC ACID) 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid LF 178 acid 2-[4-(4-CHLOROBENZOYL) PHENOXY]-2'-METHYL PROPANOIC ACID 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-propanoicaci 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic Acid, Procetofenic Acid 2-[4'-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
MDL Number	MFCD00792461
Beilstein Registry Number	2058973
Chemical Name Translation	非诺贝特酸
EC Number	255-626-9
Reaxys-RN	2058973
PubChem Substance ID	253661146

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产品应用

Fenofibric acid is the active metabolite of Fenofibrate (F248640). Increases Apolipoprotein A-I?Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transpor

安全信息

GHS Symbol

Safety Statements

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P301+P312+P330
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R50/53

RTECSUA2453000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,885,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,885,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 313 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 23(Suppl 4),S873,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1242 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year

WGK Germany3

Signal word Warning

Hazard statements

H302 Harmful if swallowed 吞食有害
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Hazard Codes Xn,N

Hazard Class9

UN Number 3077

Packing GroupIII

其他信息

MOL 文件:42017-89-0.mol
用途一:用作医药中间体
用途二:非诺贝特的中间体。