1H-[1,2,4]Oxadiazolo[4,3-A]Quinoxalin-1-One 1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮

CAS 41443-28-1 MFCD00792620

化学结构图

41443-28-1
SMILES: O=c1onc2cnc3ccccc3n12

化学属性

Mol. FormulaC9H5N3O2
Mol. Weight187.16
Melting Point160.0 to 164.0 deg-C

别名和识别编码

Chemical Name1H-[1,2,4]Oxadiazolo[4,3-A]Quinoxalin-1-One
CAS Number41443-28-1
Synonym ODQ
PubChem Substance ID160871480
MDL NumberMFCD00792620
Chemical Name Translation1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮
Reaxys-RN1109587
LabNetwork Molecule IDLN01307830
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分类

  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Inhibitors,
  • {SNA} Cyclic Nucleotide Metabolism, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Inhibitors, Guanylyl cyclase, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,

产品应用

  • 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.

相关文献及参考

  • Lee, H.G., et al.: J. Neurosci. Res., 87 269 (2009),
  • Schrammel, et al., Characterization of 1H [1,2,4]oxadiazolo[4,3a]quinoxalin1one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol. Pharmacol. 50 , 1-5, (1996) 摘要
  • Brunner, et al., Novel guanylyl cyclase inhibitor ODQ reveals role of nitric oxidebut not of cyclic-GMP in endothelin-1 secretion. FEBS Lett. 376 , 262-266, (1995) 摘要
  • Garthwaite, et al., Potent and selective inhibition of nitric oxidesensitive guanylyl cyclase by 1H[1,2,4]oxadiazolo[4,3a]quinoxalin-1-one. Mol. Pharmacol. 48 , 184-188, (1995) 摘要
  • Vielma, A., et al., Nitric Oxide Amplifies The Rat Electroretinogram. Exp. Eye Res. 91 , 700-9, (2010) 摘要

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
RTECSRO0913150
Storage condition 0-10°C

系列性分类


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