Rel-(S)-(2,8-Bis(Trifluoromethyl)Quinolin-4-Yl)((R)-Piperidin-2-Yl)Methanol Hydrochloride rel-(S)-(2,8-双(三氟甲基)喹啉-4-基)((R)-哌啶-2-基)甲醇盐酸盐
CAS 51773-92-3 MFCD00797519
化学结构图
SMILES: Cl.O[C@@H]([C@H]1CCCCN1)C1=CC(=NC2C(=CC=CC=21)C(F)(F)F)C(F)(F)F |&1:2,3|
化学属性
| Mol. Formula | C17H16F6N2O·HCl |
|---|---|
| Mol. Weight | 414.78 |
别名和识别编码
| Chemical Name | Rel-(S)-(2,8-Bis(Trifluoromethyl)Quinolin-4-Yl)((R)-Piperidin-2-Yl)Methanol Hydrochloride |
|---|---|
| Synonym | (AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride Mefloquine hydrochloride WR 14249 WR 142490 dl-Erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride |
| MDL Number | MFCD00797519 |
| PubChem Substance ID | 160871289 |
| EC Number | 257-412-0 |
| Reaxys-RN | 5203544 |
| CAS Number | 51773-92-3 |
| Merck Number | 5801 |
| Chemical Name Translation | rel-(S)-(2,8-双(三氟甲基)喹啉-4-基)((R)-哌啶-2-基)甲醇盐酸盐 |
| Wiswesser Line Notation | T66 BNJ CXFFF EYQ- BT6MTJ& JXFFF &GH |
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分类
- {SNA} Adhesion Molecules and Related Proteins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Fluorination Ready Pharma-Developed Compounds, M, Roche, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Adhesion Molecules and Related Proteins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Fluorination Ready Pharma-Developed Compounds, M, Merck, Roche, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Adhesion Molecules and Related Proteins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,
相关文献及参考
- [2]. Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545.
- [3]. Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403.
- [4]. Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.
- [1]. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6.
- [1]. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6.
- [2]. Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SP
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 130 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ACTRAQ Acta Tropica. (Schwabe & Co., Steintorstr. 13, CH-4010 Basel, Switzerland) V.1- 1944- Volume(issue)/page/year: 37,232,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 880 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ACTRAQ Acta Tropica. (Schwabe & Co., Steintorstr. 13, CH-4010 Basel, Switzerland) V.1- 1944- Volume(issue)/page/year: 37,232,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 96 mg/kg/52D-I TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - excitement Behavioral - aggression REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 154,2360,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 11 mg/kg/2W-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 114,994,199
