2-Amino-7-Isopropyl-5-Oxo-5H-Chromeno[2,3-b]Pyridine-3-Carboxylic Acid 2-氨基-7-异丙基-5-氧代-5H-苯并吡喃并[2,3-b]吡啶-3-羧酸

CAS 68302-57-8 MFCD00864790

化学结构图

68302-57-8
SMILES: CC(C)C1=CC2=C(C=C1)OC1=NC(N)=C(C=C1C2=O)C(O)=O

化学属性

Mol. FormulaC16H14N2O4
Mol. Weight298.29
Melting Point300

别名和识别编码

Chemical Name2-Amino-7-Isopropyl-5-Oxo-5H-Chromeno[2,3-b]Pyridine-3-Carboxylic Acid
CAS Number68302-57-8
Synonym Elics Amoxanox 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic Acid Aphthasol 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid AA 673 Amoxanox CHX 3673 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid Amlexanox Solfa CHX-3673 2-​Amino-​7-​(1-​methylethyl)​-​5-​oxo-​5H-​[1]​Benzopyrano[2,3-​b]​pyridine-​3-​carboxylic acid
MDL NumberMFCD00864790
Beilstein Registry Number556384
Chemical Name Translation2-氨基-7-异丙基-5-氧代-5H-苯并吡喃并[2,3-b]吡啶-3-羧酸
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分类

  • Pharmaceuticals
  • {SNA} Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, New Products
  • Intermediates & Fine Chemicals,
  • {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Inhibits release of allergic mediators from mast cells. Antiallergic; antiasthmatic.

相关文献及参考

  • Rankov, G., et al.: Ophthalmic Res., 22, 359 (1990),
  • Greer, R.O., et al.: J. Oral Mxillofac. Surg., 51, 243 (1993),

安全信息

RTECSDJ3102000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2320 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,6405,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,6405,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 13,6405,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed acti

GHS Symbol
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
WGK Germany3
Signal word
Hazard Codes Xn
Risk Statements
Precautionary statements

系列性分类


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