Cefpodoxime Proxetil 头孢泊肟酯
CAS 87239-81-4 MFCD00864906
化学结构图
SMILES: CC(C)OC(=O)OC(C)OC(=O)C1=C(CS[C@@H]2[C@H](NC(=O)/C(=N\OC)/C3=CSC(N)=N3)C(=O)N12)COC |&1:16,17|
化学属性
| Mol. Formula | C21H27N5O9S2 |
|---|---|
| Mol. Weight | 558 |
别名和识别编码
| Chemical Name | Cefpodoxime Proxetil |
|---|---|
| CAS Number | 87239-81-4 |
| Synonym | JP,USP U-76252 (RS)-1(ISOPROPOXYCARBONYLOXY)ETHYL (+)-(6R,7R)-7-[2-(2-AMINO-4-THIAZOLYL)-2-[(Z)METHOXYIMINO]ACETAMIDO]-3-METHOXYMETHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE BANAN Cefpodoxime Proxetil JPFa CefpodoximeProxet ORELOX Cefopodoximeproxetil CEFPODOXIME OTREON Cefpodoxime CS-807 CEFODOX (6r-(6-alpha,7-beta(z)))-bonyl)oxy)ethyleste R 3763 1-(((1-methylethoxy)car (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid CEFPODOXIME PROXETIL (+)-(6R,7R)-7-[2-(2-AMINO-4-THIAZOLYL)-2-[(Z)METHOXYIMINO]ACETAMIDO]-3-METHOXYMETHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE U-76253 VANTIN Cefpodoxime proxetil R-3763 CS-807, U-76252, Banan, Cefodox, Orelox, Otreon, Vantin |
| Chemical Name Translation | 头孢泊肟酯 |
| MDL Number | MFCD00864906 |
| InChIKey | LTINZAODLRIQIX-ZFEISNGRSA-N |
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分类
- Heterocycles
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- A metabolite of Cefpodoxime Proxetil (C243860). An antibacterial.
相关文献及参考
- Fujimoto, K., et al.: J. Antibiot., 40, 370 (1987),
- Utsui, Y., et al.: Antimicrob. Agents Chemother., 31, 1085 (1987),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Vo
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Blood - changes in spleen REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 36(Suppl 1),274,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 36(Suppl 1),274,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 36(Suppl 1),300,19
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 5500 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 36(Suppl 1),320,1988
