Gabapentin 加巴喷丁
CAS 60142-96-3 MFCD00865286
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分类
- {Chemicalbook} 药物: 中枢神经系统用药: 抗癫痫药
- {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Calcium Channel Modulators, G, GABA and Glycine Receptor Modulators, Inhibitors and Activators, Ion Channels, Ligand-Gated Ion Channels, Neurobiology, Neuroscience, Pfizer Compounds, Pharmacologicals, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
- {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates,
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P308+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,518,1986
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >8053 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,418,1984
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,518,1986
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >8 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,518,1986
其他信息
- 用途二:抗焦虑药。
- 用途一:用于常规抗癫痫药不能满意控制或不能耐受的局限性发作的癫痫患者,以及局限性发作并继而全身化的癫痫患者的附加治疗。
- 加巴喷丁盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 G0318 加巴喷丁 Gabapentin 5G 880元 2011/04/16 G0318 加巴喷丁 Gabapentin 25G 2640元
- TCI Shanghai:加巴喷丁 Gabapentin,>;98.0%(GC)(T)(60142-96-3)
- MSDS 信息:1-(Aminomethyl)cyclohexaneacetic acid(60142-96-3).msds
- Sigma Aldrich:60142-96-3(sigmaaldrich)
- 上游原料:叠氮化钠 --> 氯甲酸乙酯 --> 环己烷
- color:off-white
- 方法一:1,1-环己烷-7,酸单甲酯(I)和溶于含三乙胺的丙酮中的氯甲酸乙酯及溶于水的叠氮钠反应,形成的产物(Ⅱ)在20%盐酸中回流3h,得到加巴喷丁。
- MOL 文件:60142-96-3.mol