Rufinamide 卢非酰胺
CAS 106308-44-5 MFCD00865314
化学结构图
SMILES: NC(=O)C1=CN(CC2C(F)=CC=CC=2F)N=N1
化学属性
| Mol. Formula | C10H8F2N4O |
|---|---|
| Mol. Weight | 238 |
| Melting Point | 239-243 |
别名和识别编码
| Chemical Name | Rufinamide |
|---|---|
| CAS Number | 106308-44-5 |
| Synonym | 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide |
| MDL Number | MFCD00865314 |
| PubChem Substance ID | 24724595 |
| Beilstein Registry Number | 13495800 |
| Chemical Name Translation | 卢非酰胺 |
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分类
- Bases & Related Reagents
- {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Eisai, Neurobiology, Neuroscience, Novartis, Pharmacologicals, R
- Nucleotides
- Heterocycles
- Pharmaceuticals
- {SNA} Anticonvulsants, Approved
产品应用
- Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant.
相关文献及参考
- Cheung, W.K., et al.: Pharm. Res., 12, 1878 (1995),
- Cardot, J.-M., et al.: Biopharm. Drug Dispos., 19, 259 (1998),
- Palhagen, S., et al.: Epilepsy Res., 43, 115 (2001),
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R28 Very toxic if swallowed 吞咽极毒
- R38 Irritating to skin 刺激皮肤
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P304+P340+P312
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
