6-(2,3-Dichlorophenyl)-1,2,4-Triazine-3,5-Diamine 6-(2,3-二氯苯基)-1,2,4-三嗪-3,5-二胺

CAS 84057-84-1 MFCD00865333

化学结构图

84057-84-1
SMILES: Nc1nnc(-c2cccc(Cl)c2Cl)[13c](N)n1

化学属性

Mol. FormulaC9H7Cl2N5
Mol. Weight256.09
Melting Point216-220

别名和识别编码

Chemical Name6-(2,3-Dichlorophenyl)-1,2,4-Triazine-3,5-Diamine
Synonym 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine GI 267119X BW 430C GI 267119X Lamictal Lamotrigine
PubChem Substance ID160871245
EC Number281-901-8
MDL NumberMFCD00865333
Chemical Name Translation6-(2,3-二氯苯基)-1,2,4-三嗪-3,5-二胺
Beilstein Registry Number7589268
CAS Number84057-84-1
LabNetwork Molecule IDLN00193340
Reaxys-RN7589268
Merck Number5353
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分类

  • {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, L, Neurobiology, Neuroscience, Pharmacologicals
  • {SNA} Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Ind

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSXY5850700
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P310
  • P301+P310+P330
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Hazard Codes 6.1 T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
UN Number 2811
Packing GroupIII
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 342,1552,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPILAK Epilepsia (New York).  (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1-    1959-
   Volume(issue)/page/year: 25,655,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 205 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPILAK Epilepsia (New York).  (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1-    1959-
   Volume(issue)/page/year: 25,655,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2 mg/kg/30H-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 98,294,1996

Hazard Class6.1
Storage condition 0-10°C

系列性分类


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