Moclobemide 吗氯贝胺
CAS 71320-77-9 MFCD00865388
化学结构图
SMILES: O=C(NCCN1CCOCC1)C1C=CC(Cl)=CC=1
化学属性
| Mol. Formula | C13H17ClN2O2 |
|---|---|
| Mol. Weight | 269 |
| Melting Point | 136-140 |
别名和识别编码
| Chemical Name | Moclobemide |
|---|---|
| CAS Number | 71320-77-9 |
| Synonym | 4-chloro-N-[2-(4-morpholinyl)ethyl]benzamide Aurorix Moclamine Ro-11-1163, Aurorix, Manerix, Moclamine, p-Chloro-N-(2-morpholinoethyl)benzamide 4-Chloro-N-(2-(4-morpholinyl)ethyl)benzamide Aurorix Moclobemide Ro 11-1163 |
| MDL Number | MFCD00865388 |
| Chemical Name Translation | 吗氯贝胺 |
| Beilstein Registry Number | 530974 |
| PubChem Substance ID | 354333444 |
| Reaxys-RN | 530974 |
| Merck Number | 6226 |
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分类
- Pharmaceuticals
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, M, Monoamine Oxidase A, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Roche, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Intermediates & Fine Chemicals,
- Inhibitors
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, M, Monoamine Oxidase A, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Roche
产品应用
- A reversible monoamine oxidase inhibitor.
相关文献及参考
- Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985),
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P305+P351+P338+P337+P313
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P302+P352+P332+P313+P362+P364
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H302 Harmful if swallowed 吞食有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 591 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 31,909,1996
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 66 mg/kg/11D-I TOXIC EFFECTS : Vascular - BP elevation not characterized in autonomic section REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 346,1032,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 5 mg/kg/5W-I TOXIC EFFECTS : Skin and Appendages - hair REFERENCE : HUPSEC Human Psychopharmacology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.Sussex PO19 1UD, United Kingdom) V.1- 1986- Volume(issue)/page/year: 12,81,1997
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 12600 mg/kg/14D-I TOXIC EFFECTS : Blood - thrombocytopenia Blood - leukemia Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 347,1329,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 707 mg/kg TOXIC EFFECTS : Det
