N-(4-(4-(4-Fluorophenyl)piperazin-1-yl)butan-2-yl)nicotinamide N-(4-(4-(4-氟苯基)哌嗪-1-基)丁-2-基)烟酰胺
CAS 27367-90-4 MFCD00867991
化学结构图
SMILES: CC(CCN1CCN(CC1)C1C=CC(F)=CC=1)NC(=O)C1C=NC=CC=1
化学属性
| Mol. Formula | C20H25FN4O |
|---|---|
| Mol. Weight | 356.49 |
别名和识别编码
| Chemical Name | N-(4-(4-(4-Fluorophenyl)piperazin-1-yl)butan-2-yl)nicotinamide |
|---|---|
| Synonym | N-(3-(4-(p-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)nicotinamide N-(3-(4-(4-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)-3-pyridinecarboxamide Nopron 3-Pyridinecarboxamide, Niaprazine |
| CAS Number | 27367-90-4 |
| Beilstein Registry Number | 0844157 |
| Chemical Name Translation | N-(4-(4-(4-氟苯基)哌嗪-1-基)丁-2-基)烟酰胺 |
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相关文献及参考
- [2]. P G Rossi, et al. Niaprazine in the treatment of autistic disorder. J Child Neurol. 1999 Aug;14(8):547-50.
- [3]. P E Keane, et al. The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain. Neuropharmacology. 1982 Feb;21(2):163-9.
- [1]. D Scherman, et al. Molecular pharmacology of niaprazine. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):989-1001.
- [1]. D Scherman, et al. Molecular pharmacology of niaprazine. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):989-1001.
- [2]. P G Rossi, et al. Niaprazine in the treatment of autistic disorder. J Child Neurol. 1999 Aug;14(8):547-50.
- [3]. P E Keane, et al. The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain. Neuropharmacology. 1982 Feb;21(2):163-9.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #1957371
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 890 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #1957371
