1-(3-Chlorophenyl)-3-(1-Methyl-4-Oxo-4,5-Dihydro-1H-Imidazol-2-Yl)Urea 1-(3-氯苯基)-3-(1-甲基-4-氧代-4,5-二氢-1H-咪唑-2-基)脲
CAS 57653-26-6 MFCD00868019
化学结构图
SMILES: CN1CC(=O)N=C1NC(=O)NC1C=C(Cl)C=CC=1
化学属性
| Mol. Formula | C11H11ClN4O2 |
|---|---|
| Mol. Weight | 266.68 |
别名和识别编码
| Chemical Name | 1-(3-Chlorophenyl)-3-(1-Methyl-4-Oxo-4,5-Dihydro-1H-Imidazol-2-Yl)Urea |
|---|---|
| Synonym | N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea Fenobam N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea |
| MDL Number | MFCD00868019 |
| PubChem Substance ID | 24894721 |
| Chemical Name Translation | 1-(3-氯苯基)-3-(1-甲基-4-氧代-4,5-二氢-1H-咪唑-2-基)脲 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids, F, Johnson & Johnson, Neuroscience, Neurotransmission, Neurotransmitters, Others
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Excitatory Amino Acids, F, Johnson & Johnson, Neuroscience, Neurotransmission, Neurotransmitters, Other Excitatory Amino Acids, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacokinetics, Side Effects, and Analgesic Effects in Healthy Human Subjects.bioRxiv 391383;
- [3]. Keck TM, et al. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans. Psychopharmacology (Berl). 2013;229(2):253-265.
- [1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.
- [1]. Porter RH, et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.
- [2]. Laura F, et al. The Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Fenobam: Pharmacoki
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- H300 Fatal if swallowed 吞食致命
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
