PECAZINE 哌卡嗪
CAS 60-89-9 MFCD00868167
化学结构图
SMILES: CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1
化学属性
| Mol. Formula | C19H22N2S |
|---|---|
| Mol. Weight | 310.49 |
别名和识别编码
| Chemical Name | Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)- |
|---|---|
| Chemical Name Translation | 哌卡嗪 |
| Wiswesser Line Notation | T C666 BN ISJ B1- CT6NTJ A1 |
| Synonym | Meprazine 10-(1-Methyl-3-piperidyl)methyl phenothiazine Pacatal Pakatal MPMP (N-Methyl-3-piperidyl)methylphenothiazine Pecazine P 391 Mepazine Base Paxital Lacumin 10-(1-Methylpiperidyl-3-methyl)phenothiazine Pecatal Pacatal Base Mepazin Mepazine 10H-Phenothiazine, 10-((1-methyl-3-piperazinyl)methyl)- Nothiazine |
| CAS Number | 60-89-9 |
| PubChem Substance ID | 6075 |
| InChI | InChI=1S/C19H22N2S/c1-20-12-6-7-15(13-20)14-21-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)21/h2-5,8-11,15H,6-7,12-14H2,1H3 |
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相关文献及参考
- [1]. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86. Volume(issue)/page/year: 3,224,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 24,136,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,232,1954
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECI
