Limaprost
CAS 74397-12-9 MFCD00868275
化学结构图
SMILES: C[C@H](C[C@H](O)/C=C/[C@@H]1[C@@H](CCCC/C=C/C(O)=O)C(=O)C[C@H]1O)CCCC
化学属性
| Mol. Formula | C22H36O5 |
|---|---|
| Mol. Weight | 381 |
别名和识别编码
| Chemical Name | Limaprost |
|---|---|
| CAS Number | 74397-12-9 |
| Synonym | (2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic Acid (2E,11-alpha,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprost-2,13-dien-1-oic acid (2E,11?,13E,15S,17S)-11,15-Dihydroxy-17,20- 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid 17α,20-dimethyl-δ2-PGE1 17S,20-Dimethyl-trans-2,3-didehydro-PGE1 17α,20-dimethyl-δ2-PGE1 9-Oxo-11-alpha,15-alpha-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic acid Limaprost ONO 1206 OP 1206 |
| MDL Number | MFCD00868275 |
| PubChem Substance ID | 329817640 |
| Chemical Name Translation |
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分类
- Pharmaceuticals
- Chiral Reagents
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Lipids in Cell Signaling, Prostaglandins
- Intermediates & Fine Chemicals,
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, L, Lipids in Cell Signaling, Prostaglandins, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.
相关文献及参考
- Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980),
- Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981),
- Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982),
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- H300 Fatal if swallowed 吞食致命
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041368
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2041368
