(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (S)-10-[(二甲氨基)甲基]-4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]中氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮
CAS 123948-87-8 MFCD00870670
化学结构图
SMILES: CN(C)CC1C2C=C3CN4C(=CC5=C(COC(=O)[C@]5(O)CC)C4=O)C3=NC=2C=CC=1O
化学属性
| Mol. Formula | C23H23N3O5 |
|---|---|
| Mol. Weight | 421 |
别名和识别编码
| Chemical Name | (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
|---|---|
| Synonym | 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin hydrochloride hydrate NSC-609669 hydrochloride hydrate SKF-104864A hydrochloride hydrate hycamptamine hydrochloride hydrate Topotecan hydrochloride hydrate |
| MDL Number | MFCD00870670 |
| Chemical Name Translation | (S)-10-[(二甲氨基)甲基]-4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]中氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮 |
| PubChem Substance ID | 329826724 |
| LabNetwork Molecule ID | LN00188485 |
| CAS Number | 123948-87-8 |
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分类
- {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA Repair Regulators, DNA metabolism, GlaxoSmithKline, T
- {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, DNA Repair Regulators, DNA metabolism, Fluorination Ready Pharma-Developed Compounds, GlaxoSmithKline, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S22 Do not breathe dust 不要吸入粉尘；
- R46 May cause inheritable genetic damage 可能引起遗传基因损害
- R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险
