Trabectedin
CAS 114899-77-3 MFCD00874849
化学结构图
SMILES: CN1[C@H]2CC3=CC(C)=C(OC)C(O)=C3[C@@H]1[C@@H]1[C@@H]3SC[C@]4(NCCC5C=C(O)C(=CC4=5)OC)C(=O)OC[C@@H](C4C3=C(OC(C)=O)C(C)=C3OCOC3=4)N1[C@H]2O
化学属性
| Mol. Formula | C39H43N3O11S |
|---|---|
| Mol. Weight | 761.84 |
别名和识别编码
| Chemical Name | Trabectedin |
|---|---|
| CAS Number | 114899-77-3 |
| Synonym | ######## |
| Chemical Name Translation |
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分类
- Amines
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for pati
相关文献及参考
- [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.
- [3]. Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44.
- Sakai, R., et al.: Proc. Natl. Acad. Sci., 89, 11456
- [1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.
- [1]. Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15.
- [2]. Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;2
