Itopride hydrochloride 盐酸伊托必利
CAS 122892-31-3 MFCD00881710
化学结构图
SMILES: Cl.COC1=CC=C(C=C1OC)C(=O)NCC1C=CC(=CC=1)OCCN(C)C
化学属性
| Mol. Formula | C20H26N2O4.HCl |
|---|---|
| Mol. Weight | 395 |
| Melting Point | 192.0 to 196.0 deg-C |
别名和识别编码
| Chemical Name | Itopride hydrochloride |
|---|---|
| CAS Number | 122892-31-3 |
| Synonym | Ganaton HC-803 HSR-803 Itax Itopride hydrochloride N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4-dimethoxidebenzamide N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy Benzamide Hydrochloride N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride |
| MDL Number | MFCD00881710 |
| PubChem Substance ID | 253662451 |
| Chemical Name Translation | 盐酸伊托必利 |
| Reaxys-RN | 5369226 |
| Merck Number | 5244 |
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分类
- {SNA} Abbott, Acetylcholinesterase, Analytical and Industrial Enzymes, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholinesterase Inhibitors, Cholinesterase and Organophosphate Detection Reagents, Dopaminargics - Antagonists, Dopaminergics, Enzyme Inhibitors, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, I, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物,
产品应用
- Dopamine D2-receptor antagonist with anticholinesterase activity. Gastroprokinetic.
相关文献及参考
- [2]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct;31(10):1917-22.
- Iwanaga, Y., et al; Jpn. J. Pharmacol., 56, 261 (1991),
- Mushiroda, T., et al.: Drug Metab. Dispos., 28, 1231 (2000),
- [1]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8.
- [1]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8.
- [2]. Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mos
安全信息
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- R50 Very toxic to aquatic organisms 对水生生物极毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,740,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,740,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 275 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,740,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 164 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,740,1995
TYPE OF TEST : LD50 - Lethal dose, 50
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2520 mg/kg
SEX/DURATION : male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
18,87,1992