Telmisartan 替米沙坦
CAS 144701-48-4 MFCD00918125
化学结构图
SMILES: [2H]C([2H])([2H])N1C(=NC2C=CC=CC1=2)C1C=C(C)C2N=C(CCC)N(CC3C=CC(=CC=3)C3=CC=CC=C3C(O)=O)C=2C=1
化学属性
| Mol. Formula | C33H30N4O2 |
|---|---|
| Mol. Weight | 514.63 |
| TSCA | No |
| Melting Point | 261-263° |
别名和识别编码
| Chemical Name | Telmisartan |
|---|---|
| CAS Number | 144701-48-4 |
| Alfabeta Name | DIMETHYLPROPYLBIBENZOIMIDAZOLYLMETHYLBIPHENYLCARBOXYLICACID HHD417213253112[[[]]](())-------------,,,,''''''' |
| MDL Number | MFCD00918125 |
| Synonym | 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid BIBR 277 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid BIBR 277 BIBR 277 Telmisartan |
| Merck Number | 9129 |
| Reaxys-RN | 6624054 |
| PubChem Substance ID | 160870925 |
| Chemical Name Translation | 替米沙坦 |
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分类
- {SNA} Angiotensin Receptor Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Boehringer Ingelheim, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitter Receptors, Proteins and Derivatives, T
- {SNA} Angiotensin Receptor Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Boehringer Ingelheim, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience,
相关文献及参考
- [2]. Xuan H, et al. Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. J Vasc Surg. 2017 Apr 20. pii: S0741-5214(17)30100-3.
- [3]. Torika N, et al. Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice. Brain Behav Immun. 2017 Apr 3.
- [4]. Aswar U, et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr;69(2):358-364.
- [5]. Fujihara S, et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31;8(5):8536-8549.
- [1]. Maillard MP, et al. In vitro and
- [1]. Maillard MP, et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther. 2002 Sep;302(3):1089-95.
