(-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide (-)-1-(3-羟丙基)-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2,3-二氢-1H-吲哚-7-甲酰胺
CAS 160970-54-7 MFCD00930170
化学结构图
SMILES: C[C@H](CC1C=C2CCN(CCCO)C2=C(C=1)C(N)=O)NCCOC1C=CC=CC=1OCC(F)(F)F
化学属性
| Mol. Formula | C25H32F3N3O4 |
|---|---|
| Mol. Weight | 495.53 |
别名和识别编码
| Chemical Name | (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-2,3-di-hydro-1H-indole-7-carboxamide |
|---|---|
| CAS Number | 160970-54-7 |
| Synonym | ######## |
| Chemical Name Translation | (-)-1-(3-羟丙基)-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-2,3-二氢-1H-吲哚-7-甲酰胺 |
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分类
- Amines
- Aromatics
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- An ?1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.
相关文献及参考
- [2]. Villa L, et al. Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters.Br J Pharmacol. 2013 May;169(1):230-8.
- [3]. Osman NI, et al.Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.Expert Opin Pharmacother. 2012 Oct;13(14):2085-96.
- [4]. Kawahara T, et al. Silodosin inhibits the growth of bladder cancer cells and enhances the cytotoxic activity of cisplatin via ELK1 inactivation.Am J Cancer Res. 2015 Sep 15;5(10):2959-68. eCollection 2015.
- Murata, S., et al.: J. Urol., 164, 578 (2000),
- Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995),
- [1]. Maxime Rossi , Silodosin in the treatment of benign prostatic hyperplasia. Drug Des Devel Ther. 2010; 4: 291–297.
- [1]. Maxime Rossi , Silodosin in the treatment of benign prostatic hyperplasia. Drug Des Devel Ther. 2010; 4: 291–297.
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安全信息
GHS Symbol
