Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate 2-[4-(2-氧代环戊烷-1-基甲基)苯基]丙酸钠
CAS 80382-23-6 MFCD80382236
化学结构图
SMILES: CC(C(O)=O)C1C=CC(CC2CCCC2=O)=CC=1
化学属性
| Mol. Weight | 304.35 |
|---|---|
| Mol. Formula | C15H17O3.Na.2H2O |
别名和识别编码
| CAS Number | 80382-23-6 |
|---|---|
| Chemical Name | Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate |
| Synonym | Sodium 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionate Loxonin ?-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic Acid Sodium Salt Sodium Loxoprofen Loxoprofen sodium dihydrate CS 600 CS-600 alpha-Methyl-4-((2-oxocyclopentyl)methyl)benzeneacetate sodium salt |
| Wiswesser Line Notation | LVTJ B1R DY1&VO- &-NA- &QH 2 |
| Chemical Name Translation | 2-[4-(2-氧代环戊烷-1-基甲基)苯基]丙酸钠 |
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分类
- Aromatics
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. It becomes active after metabolism in the body and inh
相关文献及参考
- Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 155 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine REFERENCE : SKKNAJ Sanky
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine REFERENCE : SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 36,1,1984
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 857 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - bronchiolar constriction Lungs, Thorax, or Respiration - other changes REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 31,333,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 285 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine REFERENCE : SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 36,1,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 8 mg/kg SEX/DURATION : female 21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 36,1,1984
