9H-Dibenzo(b,d)pyran-9-one,3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy- 6,6-dimethyl-, trans-(+-)-

CAS 51022-71-0 MFCD00941490

化学结构图

51022-71-0
SMILES: CCCCCCC(C)(C)C1C=C(O)C2[C@@H]3CC(=O)CC[C@H]3C(C)(C)OC=2C=1 |&1:14,20|

化学属性

Mol. FormulaC24H36O3
Mol. Weight372.60

别名和识别编码

Chemical Name9H-Dibenzo(b,d)pyran-9-one,3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy- 6,6-dimethyl-, trans-(+-)-
CAS Number51022-71-0
Synonym Lilly 109514 (6aR,10aR)-rel- Nabilone
MDL NumberMFCD00941490
Chemical Name Translation
Wiswesser Line NotationT B666 DV IOTT&J H1 H1 LX6&1&1 NQ
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分类

  • Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cannabinoids, Cannabiol, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, N, Neat Compounds, Neurobiology, Neuroscience, Pharmacologicals
  • {SNA} Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cannabinoids, Cannabiol, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure,

产品应用

  • A synthetic cannabinoid with antiemetic, antiglaucoma, and CNS activity. Antiemetic.

相关文献及参考

  • Rubin, A., et al.: Clin. Pharmacol. Ther., 22, 85 (1977),
  • Stark, P., et al.: J. Pharmacol. Exp. Ther., 214, 124 (1980),
  • Souter, R.W., et al.: Anal. Profiles Drug Subs., 10, 499 (1981),
  • Merck 14 ,6342

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSHP8756000
Signal word Warning
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
T

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >1 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - ataxia
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   9,185,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >5 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   9,185,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1000 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   9,185,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1000 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - Straub tail
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   9,185,1987

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 348 mg/kg
SEX/DURATION            : female 14-22 day(s) after conception
                          lactating female 20 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   48,A120,1979

系列性分类


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