Tocainide hydrochloride Tocainide 盐酸盐
CAS 71395-14-7 MFCD00941502
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, T, Voltage-gated Ion Channels
- {SNA} Approved Therapeutics/Drug Candidates,
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 529 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,192,1973
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 360 mg/kg/6W-I TOXIC EFFECTS : Blood - normocytic anemia Blood - agranulocytosis REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 147,598,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 257 mg/kg/15D-I TOXIC EFFECTS : Sense Organs and Special Senses (Taste) - change in function Behavioral - tremor Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,142,1988
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 48 mg/kg/2D-I TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 61,79,1985