美拉加群 美拉加群
CAS 159776-70-2 MFCD00945676
化学结构图
SMILES: NC(=N)C1=CC=C(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(O)=O)C2CCCCC2)C=C1
化学属性
| Mol. Formula | C22H31N5O4 |
|---|---|
| Mol. Weight | 429.51 |
别名和识别编码
| Chemical Name | Melagatran |
|---|---|
| CAS Number | 159776-70-2 |
| Synonym | N-[(1R)-2-[(2S)-2-[[[[4-(Aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]glycine H-319/68 |
| Chemical Name Translation | 美拉加群 |
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分类
- Aromatics
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Synthetic thrombin inhibitor. Thrombin mutant anticoagulant antagonist. Antithrombotic.
相关文献及参考
- [2]. Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):345-51.
- Carlsson, S., et al.: Thromb. Res., 115, 9 (2005),
- Dewanjee, M., et al.: J. Nucl. Med., 22, 981 (1981),
- Goodman, S., et al.: J. Biomed. Mater. Res., 45, 240 (1999),
- [1]. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37.
- [1]. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37.
- [2]. Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):3
