Oxamflatin
CAS 151720-43-3 MFCD00949087
化学结构图
SMILES: ONC(=O)/C=C/C#CC1C=C(C=CC=1)NS(=O)(=O)C1C=CC=CC=1
化学属性
| Mol. Formula | C17H14N2O4S |
|---|---|
| Mol. Weight | 342.37 |
别名和识别编码
| Chemical Name | Oxamflatin |
|---|---|
| CAS Number | 151720-43-3 |
| Synonym | (2E)- (2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid |
| MDL Number | MFCD00949087 |
| PubChem Substance ID | 329818905 |
| Chemical Name Translation |
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分类
- Inhibitors
- Sulfur & Selenium Compounds
- {SNA} Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules for Epigenetic Research, Enzyme Inhibitors, Histone Deacetylase Inhibitors, Hydroxamic Acid Inhibitors, O, 分子生物学, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞生物学, 表观遗传学
- Pharmaceuticals
- {SNA} Antitumor Agents, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Cancer Research, Cell Biology, Enzyme Inhibitors, Epigenetics, Histone Deacetylase Inhibitors, Hydroxamic Acid Inhibitors, Molecular Biology, O
- Intermediates & Fine Chemicals
- Amines
- Aromatics
产品应用
- Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.
相关文献及参考
- Ohtani, M., et al.: J. Med. Chem., 39, 2871 (1996),
- Dear, A.E., et al.: Biochem. Biophys. Acta, 1492, 15 (2000),
- Lavoie, R., et al.: Bioorg. Med. Chem. Lett., 11, 2847 (2001),
- Hauke, J., et al., Survival Motor Neuron Gene 2 Silencing By DNA Methylation Correlates With Spinal Muscular Atrophy Disease Severity And Can Be Bypassed By Histone Deacetylase Inhibition. Hum. Mol. Genet. 18 , 304-17, (2009) 摘要
