GUGGULSTERONE E
CAS 39025-24-6 MFCD01310758
化学结构图
SMILES: C/C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]/12C
化学属性
| Mol. Formula | C21H28O2 |
|---|---|
| Mol. Weight | 312.45 |
别名和识别编码
| Chemical Name | (E)-Guggulsterone |
|---|---|
| Synonym | (17E)-Pregna-4,17(20)-diene-3,16-dione |
| MDL Number | MFCD01310758 |
| CAS Number | 39025-24-6 |
| PubChem Substance ID | 329799934 |
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分类
- {SNA} Cholesterol and Cholesterol Metabolism, Drug Efflux Pumps, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Lipids in Cell Signaling, Modulators for MDR/TAP Transporters, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, P to Q, P-Glycoprotein, Phytochemicals by Chemical Classification, Steroid, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 营养研究, 酶、抑制剂和底物
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cholesterol and Cholesterol Metabolism, Drug Efflux Pumps, Enzyme Inhibitors, E
相关文献及参考
- 1. Brobst, D.E. et al., Guggulsterone activates multiple nuclear receptors and induces CYP 3 A gene expression through the pregnane x receptor. J. Pharmacol. Exp. Ther. 310 , 528-535, (2004) 摘要
- 2. Xu, H.B., et al., Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines Chemotherapy 57 , 62-70, (2011) 摘要
- Merck 14 ,4573
安全信息
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R52/53
- R37 Irritating to respiratory system 刺激呼吸道
