(3S, 4S, 5R, 6R)-6-(ACETYLAMINO)-4,5-DIHYDROXY-3-PIPERIDINECARBOXYLIC ACID

CAS 54795-58-3 MFCD01631253

化学结构图

54795-58-3
SMILES: CC(=O)N[C@H]1NC[C@@H]([C@H](O)[C@@H]1O)C(O)=O

化学属性

Mol. FormulaC8H14N2O5
Mol. Weight218.21

别名和识别编码

Chemical NameSiastatin B
Synonym (3S, 4S, 5R, 6R)-6-(Acetylamino)-4,5-dihydroxy-3-piperidinecarboxylic acid Siastatin B
MDL NumberMFCD01631253
PubChem Substance ID24899775
CAS Number54795-58-3
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分类

  • {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Inhibitors, Inhibitors and Substrates, L to O, Neuraminidase, 分子生物学, 生化试剂, 糖生物学, 翻译后修饰, 蛋白质组学, 酶、抑制剂和底物
  • {SA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glycobiology, Inhibitors, Inhibitors and Substrates, L to O, Neuraminidase, Post-Translational Modification, Proteomics
  • {SNA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, In

相关文献及参考

  • 1. Umezawa, T., et al., Purification and characterization of a sialidase inhibitor, siastatin, produced by Streptomyces J. Antibiot. 27 , 963-969, (1974) 摘要
  • Knapp, S. , Zhao, D. Org. Lett. 2 , 4037, (2000) 摘要

安全信息

Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
RTECSTM6125400
Hazard Codes Xi
GHS Symbol
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 27,963,1974

Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. L to O - Enzyme Inhibitors by Enzyme
  7. Neuraminidase - L to O
  1. Functional Group 官能团索引
  2. aminal

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