CAS 101477-54-7 MFCD01703867-Lomerizine dihydrochloride 盐酸洛美利嗪 TAO{mole}

Lomerizine dihydrochloride 盐酸洛美利嗪

CAS 101477-54-7 MFCD01703867

化学结构图

SMILES: COC1=C(OC)C(CN2CCN(CC2)C(C2C=CC(F)=CC=2)C2C=CC(F)=CC=2)=CC=C1OC

化学属性

Mol. Formula	C27H30F2N2O3·2HCl
Mol. Weight	541.46

别名和识别编码

Chemical Name	Lomerizine dihydrochloride
Synonym
MDL Number	MFCD01703867
Beilstein Registry Number	4777497
Chemical Name Translation	盐酸洛美利嗪
CAS Number	101477-54-7
Reaxys-RN	4777497
Merck Number	5563
PubChem Substance ID	172089055

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安全信息

Safety Statements

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

WGK Germany3

Signal word

RTECSTK9189000

Hazard Codes

Risk Statements

R50 Very toxic to aquatic organisms 对水生生物极毒
R22 Harmful if swallowed 吞咽有害

UN Number

Packing GroupIII

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   8,105,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 882 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   8,105,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 706 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   8,105,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   CDREEA Cardiova

Storage condition 0-10°C