CAS 87081-36-5 MFCD01711669-Leptomycin A Leptomycin A 来源于链霉菌属 TAO{mole}

Leptomycin A Leptomycin A 来源于链霉菌属

CAS 87081-36-5 MFCD01711669

化学结构图

SMILES: C/C(/CC(C)C(O)C(C)C(=O)C(C)/C=C(\C)/C=C/CC(C)/C=C(\C)/C=C/C1OC(=O)C=CC1C)=C\C(O)=O

化学属性

Mol. Formula	C32H46O6
Mol. Weight	526.70

别名和识别编码

Chemical Name	Leptomycin A
Synonym	Jildamycin Leptomycin A Leptomycin A 来源于链霉菌属 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid Jildamycin
MDL Number	MFCD01711669
CAS Number	87081-36-5
Chemical Name Translation	Leptomycin A 来源于链霉菌属

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安全信息

WGK Germany1

Hazard Codes F,T

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S7 Keep container tightly closed 保存在严格密闭容器中；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

Risk Statements

R11 Highly flammable 非常易燃
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒

RTECSRA5391000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 13(3),203,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 10 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 38,1573,1985

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 10 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 38,1573,1985

GHS Symbol

Precautionary statements

P301+P310
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Signal word Danger