Dolasetron Mesylate 甲磺酸多拉司琼
CAS 115956-13-3 MFCD01718979
化学结构图
SMILES: O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H]1C[C@H]2C[C@H](C3)OC(=O)C1=CNC2C=CC=CC=21 |&1:10,12,14,16|
化学属性
| Mol. Formula | C19H20N2O3.CH4O3S.H2O |
|---|---|
| Mol. Weight | 438.54 |
别名和识别编码
| Chemical Name | Dolasetron Mesylate |
|---|---|
| Synonym | MDL 73147EF Anzemet Dolasetron mesylate monohydrate |
| CAS Number | 115956-13-3 |
| Chemical Name Translation | 甲磺酸多拉司琼 |
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相关文献及参考
- [1]. Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7(1):50-8.
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 2400 ug/kg TOXIC EFFECTS : Behavioral - headache Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes REFERENCE : BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 2400 ug/kg/10M-C TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - headache REFERENCE : BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 545 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 165 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993
