Alendronate Sodium 阿仑膦酸钠
CAS 121268-17-5 MFCD01748233
化学结构图
SMILES: O.O.O.[Na+].NCCCC(O)(P([O-])(O)=O)P(O)(O)=O
化学属性
| Mol. Formula | C4H12NNaO7P2.3H2O |
|---|---|
| Mol. Weight | 325 |
| Melting Point | 245 |
| Density | 1.857 |
别名和识别编码
| Chemical Name | Alendronate Sodium |
|---|---|
| Synonym | G-704,650 |
| MDL Number | MFCD01748233 |
| PubChem Substance ID | 135727181 |
| Chemical Name Translation | 阿仑膦酸钠 |
| CAS Number | 121268-17-5 |
| Reaxys-RN | 6947932 |
| Merck Number | 229 |
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分类
- {SNA} A-AM, Bioactive Small Molecule Alphabetical Index, Kinase Regulators, Lipids in Cell Signaling, Phospholipid Metabolism, 生物活性小分子, 甲羟戊酸途径中的抑制剂和激活剂, 癌症中的甲羟戊酸途径, 癌症代谢, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
- {SNA} A-AM, Bioactive Small Molecules, Cancer Metabolism, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Kinase Regulators, Lipids in Cell Signaling, Mevalonate Pathway in Cancer, Phospholipid Metabolism, Tools for Studying Farnesyl Diphosphate Synthase
产品应用
- 羟乙膦酸钠是一种骨吸收抑制剂；金合欢基二磷酸合成酶抑制剂 （farnesyl diphosphate synthase）(IC50 = 460 nM); CD45蛋白酪氨酸磷酸酯酶(protein tyrosine phosphatase )抑制剂。医药上用于治疗绝经后骨质疏松症和老年性骨质疏松症，骨质疏松症、异位骨化，如佩吉特（Paget）病、变形性骨炎、肾结石、恶性高钙血症等。
相关文献及参考
- Merck: 14,229
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Behavioral - ataxia Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature decrease REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,3229,1994
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,3229,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 700 ug/kg/7D-I TOXIC EFFECTS : Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - other changes REFERENCE : AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954- Volume(issue)/page/year: 90,1889,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 26 mg/kg
SEX/DURATION : female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - physical
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 28,3373,1994TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 510 mg/kg
SEX/DURATION : female 14 day(s) pre-mating - 20 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Maternal Effects - other effects
ReproducTYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 42 mg/kg
SEX/DURATION : male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - other measures of fertility
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 28,3319,1994其他信息
- 无臭无味。
