5-Aminoimidazole-4-carboxamide 5-氨基-1H-咪唑-4-酰胺
CAS 360-97-4 MFCD02181040
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Building Blocks, C3 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Imidazoles
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- Nucleotides
- {SNA} Analytical Standards, EP Standards, EP Standards C - D, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
- {SNA} Analytical Standards, EP Standards, EP Standards C - D,
- Amines
- Bases & Related Reagents,
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards
产品应用
- A metabolite of Temozolomide.
相关文献及参考
- Jaeken, J., et al.: Lancet, 2, 1058 (1984),
- [1]. YANG LIU. VARIABLE-TEMPERATURE 1 H-NMR AND AB INITIO STUDY OF 5-AMINO-IMIDAZOLE-4-CARBOXAMIDE (AICA): COMPETING PATHS FOR AMIDE-H SCRAMBLING. DECEMBER 2008.
安全信息
GHS Symbol
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P304+P340
- P305+P351+P338
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P332+P317
- P337+P317
- P362+P364
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6390 mg/kg/21W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,951,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 59,207,1968
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 3 mmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 400 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,89,1987
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 3 mmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10 ug/plate REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 2,1095,1977
其他信息
- Acros Organics:5-Aminoimidazole-4-carboxamide, 95%(360-97-4)
- 储运特性:库房通风低温干燥
- 用途一:医药中间体
- 用途三:阿卡明、氮烯咪胺的中间体。
- 4-氨基-5-咪唑甲酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 397550250 4-氨基-5-咪唑甲酰胺 5-Aminoimidazole-4-carboxamide 95% 25 GR 2621元 2010/06/21 397550050 4-氨基-5-咪唑甲酰胺 5-Aminoimidazole-4-carboxamide 95% 5 GR 925元
- 下游产品:替莫唑胺
- Sigma Aldrich:360-97-4(sigmaaldrich)
- 毒性分级:中毒
- 用途二:用作药物替莫唑胺中间体
- 方法一:用α-脒基-α-甲酰氨基乙酰胺盐酸盐在溶剂如二甲苯中环合制得。
- MOL 文件:360-97-4.mol
- 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
- 上游原料:甘氨酰胺
- 急性毒性:腹腔-小鼠LD50: 2000 毫克/公斤
- 可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
- 类别:有毒物品