Quetiapine hemifumarate salt 喹硫平半富马酸盐
CAS 111974-72-2 MFCD03423782
化学结构图
SMILES: OC(=O)/C=C/C(O)=O.OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C21.OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C21
化学属性
| Mol. Formula | C46H54N6O8S2 |
|---|---|
| Mol. Weight | 883 |
| Melting Point | 172-176 |
别名和识别编码
| Chemical Name | Quetiapine hemifumarate salt |
|---|---|
| Synonym | 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate Quetiapine fumarate Quetiapine Fumarate Quetiapine hemifumarate salt |
| MDL Number | MFCD03423782 |
| Beilstein Registry Number | 8378094 |
| Chemical Name Translation | 喹硫平半富马酸盐 |
| Reaxys-RN | 8378094 |
| Merck Number | 8039 |
| PubChem Substance ID | 160871365 |
| CAS Number | 111974-72-2 |
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, Serotonergics
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, AstraZeneca, Bioactive Small Molecule Alphabetical Index, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
- {SNA} Antagon
相关文献及参考
- [2]. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.
- [1]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
- [1]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.
- [2]. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.
安全信息
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
GHS Symbol
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P312+P330
- P308+P311
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- R22 Harmful if swallowed 吞咽有害
- R50/53
