CAS 71-68-1 MFCD03427563-Morphinan-6-one,4,5-alpha-epoxy-3-hydroxy-17-methyl-, hydrochloride,(5'-alpha)- Hydromorphone TAO{mole}

Morphinan-6-one,4,5-alpha-epoxy-3-hydroxy-17-methyl-, hydrochloride,(5'-alpha)- Hydromorphone

CAS 71-68-1 MFCD03427563

化学结构图

SMILES: CN1CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@H]3[C@H]1C5.Cl

化学属性

Mol. Formula	C17H19NO3.ClH
Mol. Weight	321.83

别名和识别编码

Chemical Name	Hydrochloride
CAS Number	71-68-1
Synonym	(5?)- Dilaudid 4,5-alpha-Epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride Hymorphan Laudicon Hydromorphone hydrochloride Dihydromorphinone hydrochloride Dilaudid hydrochloride
MDL Number	MFCD03427563
PubChem Substance ID	5462347
EC Number	200-762-6
Wiswesser Line Notation	T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JQ P1 &GH
Chemical Name Translation	Hydromorphone
InChI	InChI=1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2,4,10-11,16,19H,3,5-8H2,1H3;1H/t10-,11+,16-,17-;/m0./s1

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分类

Chiral Reagents
Pharmaceuticals
Intermediates & Fine Chemicals
{SNA} Alkaloids, Alphabetic, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs of Abuse, Excitatory Amino Acids - Opiod Agonists, Forensic and Veterinary Standards, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, HU - HZ, Membrane Protein Biology Tools, Morphine, Neurobiology, Neuroscience, Opioid Agonists, Opioids, Pharmacologicals,

产品应用

Analgesic (narcotic). Preparation by electrolytic reduction of Morphine.

安全信息

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSQD2625000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害

Restrict 精麻类化学品 {} 麻醉药品

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 194,296,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,238,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   6,334,1964

TYPE OF TEST

TYPE OF TEST            : L

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Behavioral - analgesia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(iss

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 21500 ug/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 123,705,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 44 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 123,705,1975