Phalloidin from Amanita phalloides 鬼笔环肽 来源于鬼笔鹅膏

CAS 17466-45-4 MFCD03427567

化学结构图

17466-45-4
SMILES: C[C@@H](O)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)(O)CO)NC(=O)[C@H]2CC3C4C=CC=CC=4NC=3SC[C@@H](NC1=O)C(=O)N1C[C@H](O)C[C@@H]1C(=O)N[C@H](C)C(=O)N2 |&1:1,3,7,12,22,35,43,46,50|

化学属性

Mol. FormulaC35H48N8O11S
Mol. Weight789
Density1.51
Boiling Point1370.5

别名和识别编码

Chemical NamePhalloidin from Amanita phalloides
MDL NumberMFCD03427567
PubChem Substance ID24898277
Beilstein Registry Number4347460
CAS Number17466-45-4
EC Number241-484-5
Synonym Phalloidine 鬼笔环肽 来源于鬼笔鹅膏
Chemical Name Translation鬼笔环肽 来源于鬼笔鹅膏
LabNetwork Molecule IDLN01327929
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分类

  • In Vivo/In Vitro Tracking of Stem Cells, Actin Inhibitors and Probes, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, General Stains/Dyes for Stem Cell Biology, General Stem Cell Biology, Mushroom, P, Stains/Dyes, Stem Cell Biology, Stem Cell Characterization, Stem Cell Differentiation, Stem Cell Expansion, Toxins and Venoms
  • {SNA} In Vivo/In Vitro Tracking of Stem Cells, Actin Inhibitors and Probes, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, General Stains/Dyes for Stem Cell Biology,
  • {SNA} In Vivo/In Vitro Tracking of Stem

相关文献及参考

  • Rebello, C.A. and Ludescher, R.D., Influence of tightly bound Mg 2+ and Ca 2+ , nucleotides, and phalloidin on the microsecond torsional flexibility of F-actin. Biochemistry 37 , 14529-14538, (1998) 摘要
  • Wang, Z., et al., Extensive Crosstalk Between O-GlcNAcylation And Phosphorylation Regulates Cytokinesis. Science Signaling 3 , ra2, (2010) 摘要
  • Merck 14 ,7196
  • Beil. 27 ,IV,9729

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P350
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
  • H300+H310+H330
Hazard Codes T+
RTECSSE9800000
Signal word
Safety Statements
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6600 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Liver - fatty liver degeneration
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 190,406,1938

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   48,61,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,2142,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Ro

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 10,35

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   TOXIA6 Toxicon.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
   UK)  V.1-    1962-  Volume(issue)/page/year: 25,1265,1987

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 umol/L
REFERENCE :
   CYTZAM Cytobiologie.  (Stuttgart, Fed. Rep. Ger.)  V.1-18, 1969-79.  For
   publisher information, see EJCBDN.  Volume(issue)/page/year: 17,73,1978

UN Number
Packing GroupII

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Actin Inhibitors and Probes - Cytoskeleton and Extracellular Matrix
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Actin Inhibitors and Probes - Cytoskeleton and Extracellular Matrix
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Stem Cell Biology - Cell Biology
  4. General Stem Cell Biology - Stem Cell Biology
  5. Stem Cell Characterization - General Stem Cell Biology
  6. General Stains/Dyes for Stem Cell Biology - Stem Cell Characterization

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