(1r,4r)-4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexan-1-ol (1r,4r)-rel-4-(4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)-1H-咪唑-1-基)环己醇

CAS 193551-21-2 MFCD03792786

化学结构图

193551-21-2
SMILES: COC1=NC=CC(=N1)C1=C(N=CN1[C@@H]1CC[C@@H](O)CC1)C1=CC=C(F)C=C1 |&1:13,16|

化学属性

Mol. FormulaC20H21N4O2F
Mol. Weight368.40
Melting Point206-207.2 °C

别名和识别编码

Chemical Name(1r,4r)-4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexan-1-ol
CAS Number193551-21-2
Synonym trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol
MDL NumberMFCD03792786
PubChem Substance ID329824431
Chemical Name Translation(1r,4r)-rel-4-(4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)-1H-咪唑-1-基)环己醇
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分类

  • {SA} Approved Therapeutics/Drug C
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
  • Heterocycles
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, GlaxoSmithKline, Kinase/Phosphatase Biology, Mitogen-Activated Protein Kinase (MAPK), P to Q, Protein Kinase Inhibitors, S, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, p38 MAP Kinase Inhibitors, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物

产品应用

  • SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. A protein kinase inhibitor

相关文献及参考

  • Liu, Z., et al.: Stroke, 38, 146 (2007),
  • Takahashi, K., et al.: J. Exp. Med., 201, 647 (2005),
  • Underwood, D., et al.: J. Pharmacol. Exp. Ther., 293, 281 (2000),

安全信息

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. p38 MAP Kinase Inhibitors - P to Q
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. Mitogen-Activated Protein Kinase (MAPK) - Serine/Threonine Kinase Inhibitors

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